Family history of colorectal cancer in BRAF p.V600emutated colorectal cancer cases

DD Buchanan; AK Win; MD Walsh; RJ Walters; M Clendenning; B Nagler; SA Pearson; FA Macrae; S Parry; J Arnold; I Winship; GG Giles; NM Lindor; JD Potter; JL Hopper; C Rosty; JP Young; MA Jenkins

Journal article

Family history of colorectal cancer in BRAF p.V600emutated colorectal cancer cases

DD Buchanan, AK Win, MD Walsh, RJ Walters, M Clendenning, B Nagler, SA Pearson, FA Macrae, S Parry, J Arnold, I Winship, GG Giles, NM Lindor, JD Potter, JL Hopper, C Rosty, JP Young, MA Jenkins

Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2013

DOI: 10.1158/1055-9965.EPI-12-1211

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Abstract

Background: Previous reports suggest that relatives of colorectal cancer (CRC)-affected probands carrying the BRAF p.V600E mutation are at an increased risk of CRC and extracolonic cancers (ECC). In this study, we estimated the association between a family history of either CRC or ECC and risk of CRC with a BRAF p.V600E mutation. Methods: Population-based CRC cases (probands, ages 18-59 years at diagnosis), recruited irrespective of family cancer history, were characterized for BRAF p.V600E mutation and mismatch repair (MMR) status. ORs and 95% confidence intervals (CI) were estimated using multivariable logistic regression. Results: The 690 eligible probands showed a mean age at CRC diagnos..

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University of Melbourne Researchers

Daniel Buchanan Author

Aung Ko Win Author

Mark Clendenning Author

Finlay Macrae Author

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Awarded by National Cancer Institute

Funding Acknowledgements

This work was financially supported by a NHMRC project grant 1025799 and by the National Cancer Institute, NIH under RFA #CA-95-011 and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators of Australasian Colorectal Cancer Family Registry (U01 CA097735).